Research outputs

We firmly believe in an evidence-based approach, and therefore our team regularly publishes new research to provide evidence for the utility of our approach. Read more about research published below.

Prevalence of undiagnosed primary biliary cholangitis and the potential utility of a ‘case-finding’ approach.

Hutchison K, et al 2021

Patients with indicators of primary biliary cholangitis were not investigated in line with guidance, and even those with appropriate tests in primary care were frequently not referred.

Delayed diagnosis in Hereditary Haemochromatosis – potential utility of ‘case-finding’ approach

Kitchin A, et al.

Demonstrated the delay in referral and diagnosis for genetic haemochromatosis – indicating the potential for a ‘case-finding’ approach.

A cumulative liver damage index (CLDI) identifies patients at risk of significant liver disease

Wesley E, et al.

Demonstrated the potential utility of longitudinal analysis of time trends in laboratory data as a powerful tool for case finding. The ability to perform these searches rapidly is a unique feature of the system developed.

Young adults are at increasing risk of chronic liver disease and can be identified using a novel case finding database

Creamer J, et al.

The system developed can demonstrate clearly that young adults are frequently under investigated for liver disease, and also that they can be individually identified and recalled for treatment.

Association of a cumulative liver damage index (CLDI-ALT) and thrombocytopenia with advanced liver disease and the potential utility in a case finding approach

Owen C, et al. 2023

Demonstrates that the system developed can identify patients at high risk of end stage liver disease – these are patients that have a significant risk of presenting to secondary care with irreversible / fatal liver disease in the next few months to years.

Association of a cumulative liver damage index and thrombocytopenia with advanced liver disease – utility in a case finding approach

Gormley S, et al. 2023

Demonstrates that the system developed can identify patients at high risk of end stage liver disease – these are patients that have a significant risk of presenting to secondary care with irreversible / fatal liver disease in the next few months to years.

Patients with persistently abnormal liver biochemistry are under-investigated and can be rapidly identified using a novel case-finding database

Mohamed A, et al. 2023

This abstract showed that the system can identify patients on the basis of longitudinal data with persistently abnormal liver function tests who have not had a ‘non-invasive liver screen’ – panel of blood tests to identify laboratory definable liver disease.

Patients with persistently abnormal liver biochemistry are under-investigated and can be rapidly identified using a novel case-finding database

Jobson T, et al. 2023

This abstract showed that the system can identify patients on the basis of longitudinal data with persistently abnormal liver function tests who have not had a ‘non-invasive liver screen’ – panel of blood tests to identify laboratory definable liver disease.

Patients with Hepatitis B infection are highly represented in deprived areas, less engaged with healthcare and can be rapidly identified using a novel case-finding database to help achieve the Chronic Hepatitis B Elimination 2030 goal

Mohamed A, et al. 2023

This presentation demonstrated the utility of the case finding approach to target patients in deprived areas with Hepatitis B.

Patients with Hepatitis B infection are highly represented in deprived areas, less engaged with healthcare and can be rapidly identified using a novel case-finding database to help achieve the Chronic Hepatitis B Elimination 2030 goal

Mohamed A, et al. 2023

This presentation demonstrated the utility of the case finding approach to target patients in deprived areas with Hepatitis B

A novel case finding database can be utilised to identify and target individuals in areas of deprivation at risk of advanced liver disease

Creamer J, et al. 2023

This abstract showed that the system can use the Index of Multiple Deprivation to target case-finding in areas of deprivation.

A novel case finding database can be utilised to identify and target individuals in areas of deprivation at risk of advanced liver disease

Owen C, et al. 2023

This abstract showed that the system can use the Index of Multiple Deprivation to target case-finding in areas of deprivation.

Identifying treatment naïve and undiagnosed primary biliary cholangitis patients using a novel case finding database and treatment pathway

Jobson T, et al. 2024

This abstract is the first real world data from the Somerset Liver Improvement Project – using the case finding data base to identify patients with PBC.

Identifying treatment naïve and undiagnosed primary biliary cholangitis patients using a novel case finding database and treatment pathway

Owen C, et al. 2024

This abstract is the first real world data from the Somerset Liver Improvement Project – using the case finding data base to identify patients with PBC.

Defining the data requirement to achieve the hepatitis C elimination in the United Kingdom: The Somerset Liver Improvement Project

Saunsbury E, et al. 2024

This abstract shows the potential utility of the case finding database for missing Hepatitis C patients

Defining the data requirement to achieve the hepatitis C elimination in the United Kingdom: The Somerset Liver Improvement Project

Mohamed A, et al. 2024

This abstract shows the potential utility of the case finding database for missing Hepatitis C patients

The patient experience of a new ‘referral’ pathway for liver disease in The Somerset Liver Improvement Project

Owen C, et al. 2024

This abstract presents the first real world data from the Somerset Liver Improvement Project including new pathways of care.

The patient experience of a new ‘referral’ pathway for liver disease in The Somerset Liver Improvement Project

Owen C, et al. 2024

This abstract presents the first real world data from the Somerset Liver Improvement Project including new pathways of care.

Data driven clinical trial recruitment - from the common to the rare

Miller R, et al. 2024

This abstract shows the potential power of hepatoSIGHT in generating cohorts for clinical trials

Data driven clinical trial recruitment - from the common to the rare

Miller R, et al. 2024

This abstract shows the potential power of hepatoSIGHT in generating cohorts for clinical trials

Defining the data requirement to improve Hepatitis D co-infection detection in the United Kingdom: The Somerset Liver Improvement Project

Saunsbury E, et al. 2024

This abstract shows how hepatoSIGHT may be used to identify undiagnosed hepatitis D patients in the UK.

The Somerset Liver Improvement Project – implementation of a case finding tool, the first 100 patients

Owen C, et al. 2025

This abstract shows the potential power of hepatoSIGHT to allow clinicians to rapidly and easily identify patients for care.

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